CD20 anticorps

N° du produit ABIN6297696

Cet anticorps anti-CD20 est un anticorps Souris Monoclonal détectant CD20 dans FACS, IF et Func. Adapté pour Humain.

Aperçu rapide pour CD20 anticorps (ABIN6297696)

Antigène: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD20 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Détail du produit anti-CD20 anticorps

Fonction: Mouse anti-Human CD20 Antibody [Sodium Azide Free]

Specificité: Predominantly cell surface with some cytoplasmic

Purification: Stimulated human leukocytes were used as the immunogen for this CD20 antibody.

Immunogène: Stimulated human leukocytes were used as the immunogen for this CD20 antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
Functional Testing (Order Ab without BSA & Azide),

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur CD20

Antigène: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Autre désignation: B-lymphocyte antigen CD20

Sujet:

Target Description: This antibody recognizes a protein of 33-37 kDa, identified as CD20 (Workshop V, Code CD20.12). The antibody recognizes the extracellular domain of the protein. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, Bcell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of Bcells and its expression is restricted to normal and neoplastic Bcells, being absent from all other leukocytes and tissues. It is expressed by pre Bcells and persists during all stages of Bcell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting Bcells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in Bcell activation and cell cycle progression.

Gene Symbol: MS4A1///CD20

ID gène: 931

UniProt: P11836